Efficacy of recombinant Bacillus Calmette-Guérin containing dltA in in vivo three-dimensional bio-printed bladder cancer-on-a-chip and ex vivo orthotopic mouse model.

Joongwon Choi Tae Young Jung Jung Hoon Kim Sejung Maeng Su Jeong Kang Mirinae Kim Young Wook Choi Se Young Choi Sung-Hwan Kim In Ho Chang

Published in: Investigative and clinical urology (2023)

In conclusion, rBCG-dltA has the potential to have better anti-tumor activity and immunomodulatory effects than BCG. Furthermore, high-throughput BCOCs have potential to reflect the bladder cancer microenvironment.

Keyphrases

high throughput
mouse model
stem cells
muscle invasive bladder cancer
single cell
climate change
bacillus subtilis