Biochemical and Epigenetic Insights into L-2-Hydroxyglutarate, a Potential Therapeutic Target in Renal Cancer.

Sandeep Balu ShelarEun-Hee ShimGarrett J BrinkleyAnirban KunduFrancesca CarobbioTyler PostonJubilee TanVishwas ParekhDaniel BensonDavid K CrossmanPhillip J BuckhaultsDinesh RakhejaRichard KirkmanYusuke SatoSeishi OgawaShilpa DuttaSadanandan E VeluEthan EmberleyAlison PanJason ChenTony HuangDevin AbsherAnja BeckerConrad KunickSunil Sudarshan

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)

Collectively, our studies provide biochemical and mechanistic insight into the biology of this small molecule and provide new opportunities for treating L-2-HG-driven kidney cancers.

Keyphrases

small molecule
papillary thyroid
dna methylation
squamous cell
gene expression
protein protein
childhood cancer
case control
squamous cell carcinoma
living cells
climate change
single molecule