Partial rescue of naturally occurring active site factor X variants through decreased inhibition by tissue factor pathway inhibitor and antithrombin.
Herm Jan M BrinkmanMagdalena GierulaJoseph TemenuMichael A LaffanDavid A LanePublished in: Journal of thrombosis and haemostasis : JTH (2019)
Factor X Nottingham and Taunton both display decreased proteolytic activity. However, their reduced activity in plasma triggered by low TF can be rescued by decreased inhibition by the natural FXa inhibitors, TFPI and AT.
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