The central role of Sphingosine kinase 1 in the development of neuroendocrine prostate cancer (NEPC): A new targeted therapy of NEPC.

Cheng-Fan LeeYu-An ChenElizabeth HernandezRey-Chen PongShihong MaMia HofstadPayal KapurHaiyen ZhauLeland Wk ChungChih-Ho LaiHo LinMing-Shyue LeeGanesh V RajJer-Tsong Hsieh

Published in: Clinical and translational medicine (2022)

SphK1 plays a central role in NEPC development, which offers a new target for this lethal cancer using clinically approved SphK1 inhibitors.

Keyphrases

prostate cancer
papillary thyroid
radical prostatectomy
tyrosine kinase
lymph node metastasis