Pharmacological rescue of cognitive function in a mouse model of chemobrain.

Lien D Nguyen Tom T Fischer Barbara E Ehrlich

Published in: Molecular neurodegeneration (2021)

We establish the InsP3R calcium pathway and impaired neuronal morphology as mechanisms for paclitaxel-induced cognitive impairment. Our findings suggest lithium and PKC inhibitors as candidate agents for preventing chemotherapy-induced cognitive impairment.

Keyphrases

cognitive impairment
chemotherapy induced
mouse model
high glucose
diabetic rats
drug induced
endothelial cells
cerebral ischemia
oxidative stress
solid state
blood brain barrier