Login / Signup

The co-existence of NS5A and NS5B resistance-associated substitutions is associated with virologic failure in Hepatitis C Virus genotype 1 patients treated with sofosbuvir and ledipasvir.

Seiichi MawatariKohei OdaKazuaki TabuSho IjuinKotaro KumagaiKunio FujisakiMasafumi HashiguchiYukiko InadaHirofumi UtoYasunari HiramineTakeshi KureTakeshi HoriOki TaniyamaAi KasaiTsutomu TamaiAkihiro MoriuchiAkio Ido
Published in: PloS one (2018)
Although SOF/LDV therapy resulted in a high SVR12 rate, coexisting NS5A and NS5B RASs were associated with virologic failure. These results might indicate that the coexisting baseline RASs influence the therapeutic effects of SOF/LDV.
Keyphrases
  • hepatitis c virus
  • dengue virus
  • human immunodeficiency virus
  • zika virus
  • hiv infected
  • antiretroviral therapy
  • aedes aegypti
  • bone marrow
  • mesenchymal stem cells
  • hepatitis c virus infection