Oxycodone target concentration dosing for acute pain in children.
James Denzil MorseJacqueline A HannamBrian Joseph AndersonHannu KokkiMerja KokkiPublished in: Paediatric anaesthesia (2021)
Simulation was used to suggest loading and maintenance doses to attain an oxycodone concentration of 35 mcg.L-1 predicted in adults. Although the covariates age and weight contribute 92% variability for clearance, there remains variability accounting for 16% of concentrations outside the target range. Duration of analgesic effect after ceasing infusion is anticipated to be longer in neonates where context-sensitive halftime is greater than older children and adults.