Comprehensive Genomic Analysis of Translocation Renal Cell Carcinoma Reveals Copy-Number Variations as Drivers of Disease Progression.

Julian MarconRenzo G DiNataleAlejandro SanchezRitesh R KotechaSounak GuptaFengshen KuoVladimir MakarovAmar SandhuRoy ManoAndrew W SilagyKyle A Blum Daniel E NassauNicole E BenfanteMichael V OrtizMaria Isabel CarloTimothy A ChanRobert J Motzer Martin H VossJonathan ColemanPaul RussoVictor ReuterA Ari HakimiEd Reznik

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

Tumors molecularly defined by increased copy-number variations were associated with aggressive disease in tRCC. A higher burden of genomic events in adults compared with pediatric cases likely reflects a more aggressive clinical course. The unique immunophenotypic characteristics of tRCC merit further exploration.

Keyphrases

copy number
mitochondrial dna
renal cell carcinoma
genome wide
dna methylation
risk factors
gene expression
young adults