Pigment Epithelium-Derived Factor: Inhibition of Phosphorylation of Insulin Receptor (IR)/IR Substrate (IRS), Osteogeneration from Adipocytes, and Increased Levels Due to Doxorubicin Exposure.
Isobel C JonesRevathy CarnagarinJo ArmstrongDaphne P L LinMia Baxter-HollandMina ElahyCrispin R DassPublished in: Pharmaceutics (2023)
PEDF may be used to regenerate bone from adipose tissue in cases of trauma such as fractures or bone cancers. The increased presence of PEDF in doxorubicin-treated tumour cells need further exploration, and could be useful therapeutically in future. The safety of PEDF administration in vivo was further demonstrated in this study.
Keyphrases
- adipose tissue
- bone mineral density
- drug delivery
- induced apoptosis
- type diabetes
- cancer therapy
- cell cycle arrest
- insulin resistance
- bone loss
- soft tissue
- bone regeneration
- current status
- cell death
- signaling pathway
- body composition
- glycemic control
- metabolic syndrome
- skeletal muscle
- young adults
- binding protein
- cell proliferation
- weight loss