DOCK4 Regulation of Rho GTPases Mediates Pulmonary Vascular Barrier Function.

Pascal YazbeckXavier CullerePaul BennettVijay YajnikHuan WangKenji KawadaVanessa M DavisAsit ParikhAndrew KuoVijayashree MysoreTimothy HlaDavid S MilstoneTanya N Mayadas

Published in: Arteriosclerosis, thrombosis, and vascular biology (2022)

Our findings indicate that DOCK4 maintains AJs necessary for lung vascular barrier function by establishing the normal balance between RhoA (Ras homolog family member A) and Rac-1-mediated actin cytoskeleton remodeling, a previously unappreciated function for the atypical GEF family of molecules. Our studies also identify S1P as a potential upstream regulator of DOCK4 activity.

Keyphrases

pulmonary hypertension
cell migration
transcription factor
protein kinase
case control
wild type
climate change
smooth muscle