Feasibility and Toxicity of Interval-Compressed Chemotherapy in Asian Children and Young Adults with Sarcoma.
Jia-Hui HuangShu-Huey ChenYu-Mei LiaoYu-Chien KaoWan-Ling HoHsi ChangMin-Lan TsaiHsin-Lun LeeChia-Chun KuoSung-Hui TsengChia-Yau ChangKevin Li-Chun HsiehLong-Sheng LuYin-Ju ChenJeng-Fong ChiouTsung-Han HsiehYun-Ru LiuWayne HsuWei-Tang LiYu-Chung WuWei-Ciao WuJinn-Li WangJia-Jia TsaiKeita TerashimaChikako KiyotaniTai-Tong WongJames S MiserYen-Lin LiuPublished in: Journal of personalized medicine (2023)
Twelve Asian patients with sarcoma received interval-compressed (ic-) chemotherapy scheduled every 14 days with a regimen of vincristine (2 mg/m 2 ), doxorubicin (75 mg/m 2 ), and cyclophosphamide (1200-2200 mg/m 2 ) (VDC) alternating with a regimen of ifosfamide (9000 mg/m 2 ) and etoposide (500 mg/m 2 ) (IE), with filgrastim (5-10 mcg/kg/day) between cycles. Carboplatin (800 mg/m 2 ) was added for CIC-rearranged sarcoma. The patients were treated with 129 cycles of ic-VDC/IE with a median interval of 19 days (interquartile range [IQR], 15-24 days. Median nadirs (IQR) were neutrophil count, 134 (30-396) × 10 6 /L at day 11 (10-12), recovery by day 15 (14-17) and platelet count, 35 (23-83) × 10 9 /L at day 11 (10-13), recovery by day 17 (14-21). Fever and bacteremia were observed in 36% and 8% of cycles, respectively. The diagnoses were Ewing sarcoma (6), rhabdomyosarcoma (3), myoepithelial carcinoma (1), malignant peripheral nerve sheath tumor (1), and CIC-DUX4 Sarcoma (1). Seven of the nine patients with measurable tumors responded (one CR and six PR). Interval-compressed chemotherapy is feasible in the treatment of Asian children and young adults with sarcomas.
Keyphrases
- young adults
- peripheral nerve
- end stage renal disease
- locally advanced
- newly diagnosed
- chronic kidney disease
- squamous cell carcinoma
- high grade
- radiation therapy
- low dose
- peritoneal dialysis
- peripheral blood
- middle aged
- clinical trial
- patient reported outcomes
- cancer therapy
- chemotherapy induced
- multidrug resistant
- childhood cancer
- combination therapy