Bi-aryl Analogues of Salicylic Acids: Design, Synthesis and SAR Study to Ameliorate Endoplasmic Reticulum Stress.

Ye Eun KimDong Hwan KimAmi ChoiSeoul JangKwiwan JeongYoung-Mi KimTae-Gyu Nam

Published in: Drug design, development and therapy (2021)

Anti-ER stress activity and toxicity profile of bi-aryl analogues of SA could provide a novel platform for potential therapy for protein misfolding diseases.

Keyphrases

endoplasmic reticulum stress
induced apoptosis
molecular docking
oxidative stress
high throughput
structure activity relationship
amino acid
human health
climate change