Dual recognition element-controlled logic DNA circuit for COVID-19 detection based on exonuclease III and DNAzyme.
Jiafeng PanYing HeZhi LiuJunhua ChenPublished in: Chemical communications (Cambridge, England) (2021)
Two fragments of the COVID-19 genome (specific and homologous) were used as two inputs to construct an AND logic gate for COVID-19 detection based on exonuclease III and DNAzyme. The detection sensitivity of the assay can reach fM levels. Satisfactory recovery values were obtained in real sample analysis.