Selective whole-genome sequencing of Plasmodium parasites directly from blood samples by nanopore adaptive sampling.
Katlijn De MeulenaereWim L CuypersJulia M GauglitzPieter GuetensAnna Rosanas-UrgellKris LaukensBart CuypersPublished in: mBio (2023)
reads, which simplifies and shortens the timeline from blood collection to parasite sequencing. In addition, we show that the obtained data can be used for monitoring genetic markers, or to generate nearly complete genomes. Finally, owing to its inherent mobility, this technology can be easily applied on-site in endemic areas where patients would benefit the most from genomic surveillance.