β-micrustoxin (Mlx-9), a PLA 2 from Micrurus lemniscatus snake venom: biochemical characterization and anti-proliferative effect mediated by p53.

Natália Fernanda Teixeira Dos SantosAndréia de Souza ImbergDouglas Oscar Ceolin MarianoAngelina Cirelli de MoraesJessica Andrade-SilvaCristina Maria FernandesAna Cláudia SobralKarina Cristina GiannottiWilson M Tatagiba KuwabaraDaniel Carvalho PimentaDurvanei Augusto MariaMaria Regina Lopes SandovalSolange Castro Afeche

Published in: The journal of venomous animals and toxins including tropical diseases (2022)

venom could inhibit cell proliferation through p53, p21 and p27 activation thus imposing cell cycle arrest at the checkpoint G2/M.

Keyphrases

cell cycle arrest
pi k akt
cell proliferation
cell death
cell cycle
dna damage
signaling pathway