Hyperbranched polyphthalocyanine micelles with dual PTT/PDT functions for bacteria eradication under an NIR window.
Ying DuGuangyu ChuRui YuRui CuiYuling WangYiyong MaiMing GuanFugui XuYongfeng ZhouPublished in: Chemical communications (Cambridge, England) (2023)
A Zinc phthalocyanine-based (ZnPc-PA) polymeric micelle around 70 nm and with dual-modal PTT/PDT functions for non-antibiotic bacteria eradication was developed. It showed an excellent bacterial killing efficiency of 95.2% and 96.7% in vitro against Methicillin-resistant Staphylococcus aureus (MRSA) and its biofilm, respectively. Furthermore, the in vivo experiments proved its great potential for implant-associated infection (IAI).
Keyphrases
- methicillin resistant staphylococcus aureus
- photodynamic therapy
- staphylococcus aureus
- drug delivery
- drug release
- fluorescence imaging
- helicobacter pylori infection
- cancer therapy
- pseudomonas aeruginosa
- biofilm formation
- candida albicans
- soft tissue
- escherichia coli
- helicobacter pylori
- human health
- risk assessment
- oxide nanoparticles
- hyaluronic acid
- cystic fibrosis