High-resolution profiles of the Streptococcus mitis CSP signaling pathway reveal core and strain-specific regulated genes.
G SalvadoriR JungesH A ÅmdalT ChenD A MorrisonFernanda Cristina PetersenPublished in: BMC genomics (2018)
Overall, comparison of the global transcriptome in response to CSP shows the conservation of the ComE and SigX-core regulons in competent S. mitis isolates, as well as species and strain-specific genes. Although some S. mitis exhibit truncations in key competence genes, this study shows that in transformable strains, competence seems to depend on the same core genes previously identified in S. pneumoniae.
Keyphrases
- genome wide
- high resolution
- signaling pathway
- bioinformatics analysis
- genome wide identification
- dna methylation
- escherichia coli
- single cell
- gene expression
- transcription factor
- epithelial mesenchymal transition
- mass spectrometry
- rna seq
- cell proliferation
- candida albicans
- genetic diversity
- liquid chromatography
- induced apoptosis