Reflections on the state of diabetes research and prospects for treatment.
Domenico AcciliWen DuTakumi KitamotoTaiyi KuoWendy McKimpsonYasutaka MiyachiMaria MukhanovaJinsook SonLiheng WangHitoshi WatanabePublished in: Diabetology international (2022)
Research on the etiology and treatment of diabetes has made substantial progress. As a result, several new classes of anti-diabetic drugs have been introduced in clinical practice. Nonetheless, the number of patients achieving glycemic control targets has not increased for the past 20 years. Two areas of unmet medical need are the restoration of insulin sensitivity and the reversal of pancreatic beta cell failure. In this review, we integrate research advances in transcriptional regulation of insulin action and pathophysiology of beta cell dedifferentiation with their potential impact on prospects of a durable "cure" for patients suffering from type 2 diabetes.
Keyphrases
- type diabetes
- glycemic control
- end stage renal disease
- chronic kidney disease
- newly diagnosed
- cardiovascular disease
- blood glucose
- ejection fraction
- prognostic factors
- clinical practice
- healthcare
- single cell
- insulin resistance
- weight loss
- cell therapy
- adipose tissue
- combination therapy
- patient reported outcomes
- bone marrow
- current status
- smoking cessation
- risk assessment