Quercetin Effects on Cell Cycle Arrest and Apoptosis and Doxorubicin Activity in T47D Cancer Stem Cells.

Ebrahim AziziShamileh FouladdelTahereh Komeili MovahhedFarzan ModaresiElmira BarzegarMohammad H GhahremaniSeyed Naser OstadShekoufeh Atashpour

Published in: Asian Pacific journal of cancer prevention : APJCP (2022)

These outcomes suggested that CSCs are a minor population of cancer cells, which play a significant role in drug resistance by being quiescent, slow cycling and resistance to apoptosis. Furthermore, our data showed that adding Quercetin to Doxorubicin is an effective approach for the treatment of both CSCs and bulk tumor cells.

Keyphrases

cell cycle arrest
cancer stem cells
cell death
pi k akt
drug delivery
cancer therapy
signaling pathway
electronic health record
high intensity
cell proliferation
big data
combination therapy
adipose tissue