Down-Regulation of Dkk-1 in Platelets of Patients With Axial Spondyloarthritis.

Marcin CzepielMałgorzata StecMariusz KorkoszZofia GułaPrzemysław BłyszczukJarosław BaranMaciej Siedlar

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2021)

Our preliminary observations suggest that dysfunction of the megakaryocyte/platelet axis might be responsible for reduced serum Dkk-1 levels in patients with axial SpA. Dkk-1 is down-regulated in the platelets of patients with axial SpA, a mechanism that might play a role in new bone formation.

Keyphrases

oxidative stress
ankylosing spondylitis
transcription factor
disease activity
rheumatoid arthritis
systemic lupus erythematosus