Alterations in BAP1 Are Associated with Cisplatin Resistance through Inhibition of Apoptosis in Malignant Pleural Mesothelioma.

Kathrin OehlBart Vrugt Ulrich Wagner Michaela B KirschnerMayura MeerangWalter WederEmanuela Felley-Bosco Bernd WollscheidKatrin BankovMelanie C DemesIsabelle Opitz Peter J Wild

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

Alterations in BAP1 in MPM were a negative predictor for response to chemotherapy and could possibly be used as a companion biomarker for treatment decision.

Keyphrases

oxidative stress
cell death
locally advanced
squamous cell carcinoma
combination therapy
cell proliferation
chemotherapy induced