Exploring the biological functional mechanism of the HMGB1/TLR4/MD-2 complex by surface plasmon resonance.

Mingzhu HeMarco E BianchiTom R ColemanKevin J TraceyYousef Al-Abed

Published in: Molecular medicine (Cambridge, Mass.) (2018)

These findings not only suggest a model whereby HMGB1 interacts with TLR4/MD-2 in a two-stage process but also explain how the A-box domain and 2G7 inhibit HMGB1.

Keyphrases

toll like receptor
inflammatory response
immune response
molecular dynamics
binding protein
transcription factor