Clinical Characteristics and Prognosis of Gastric Cancer Patients with BRCA 1/2 Germline Mutations: Report of Ten Cases and a Literature Review.

Halpern NaamaAlbert GrinshpunBen BoursiTalia GolanOfer MargalitDan AderkaEitan FriedmanYael LaitmanAyala HubertLuna KadouriTamar HamburgerInbal Barnes-KedarZohar LeviIrit Ben-AharonBaruch BrennerYael GoldbergTamar PeretzEinat Shacham-Shmueli

Published in: OncoTargets and therapy (2020)

These preliminary data suggest that gBRCAm in GC patients are associated with a favorable prognosis. Furthermore, gBRCAm might be a predictive biomarker to DNA-damaging agents response in GC patients, similarly to its established role in other malignancies. Further research is needed to confirm our findings.

Keyphrases

end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
prognostic factors
machine learning
oxidative stress
case report
electronic health record
big data
cell free
circulating tumor
liquid chromatography