Role of altered proteostasis network in chronic hypobaric hypoxia induced skeletal muscle atrophy.
Akanksha AgrawalRicha RathorRavi KumarGeetha SuryakumarLilly GanjuPublished in: PloS one (2018)
The disrupted proteostasis network was tightly coupled to degradative pathways, altered anabolic signaling, inflammation, and apoptosis under chronic hypoxia. Severe and prolonged hypoxia exposure affected the protein homeostasis which overwhelms the muscular system and tends towards skeletal muscle atrophy.