Login / Signup

Role of altered proteostasis network in chronic hypobaric hypoxia induced skeletal muscle atrophy.

Akanksha AgrawalRicha RathorRavi KumarGeetha SuryakumarLilly Ganju
Published in: PloS one (2018)
The disrupted proteostasis network was tightly coupled to degradative pathways, altered anabolic signaling, inflammation, and apoptosis under chronic hypoxia. Severe and prolonged hypoxia exposure affected the protein homeostasis which overwhelms the muscular system and tends towards skeletal muscle atrophy.
Keyphrases
  • skeletal muscle
  • oxidative stress
  • insulin resistance
  • endothelial cells
  • endoplasmic reticulum stress
  • drug induced
  • early onset
  • cell death
  • type diabetes
  • metabolic syndrome
  • resistance training
  • body composition