Anti-VEGF therapy prevents Müller intracellular edema by decreasing VEGF-A in diabetic retinopathy.
Tianqin WangChaoyang ZhangHai XieMengmeng JiangHaibin TianLixia LuGuo-Tong XuLin LiuJingfa ZhangPublished in: Eye and vision (London, England) (2021)
Ranibizumab protected Müller cells from diabetic intracellular edema through the up-regulation of Kir4.1 and AQP4 by directly binding VEGF-A. It also caused a reduction in intracellular osmotic pressure.