A novel phage carrying capsule depolymerase effectively relieves pneumonia caused by multidrug-resistant Klebsiella aerogenes.
Xiaohu CuiBing DuJunxia FengYanling FengZheng FanJinfeng ChenJinghua CuiLin GanTongtong FuZiyan TianRui ZhangChao YanHanqing ZhaoWenjian XuZiying XuZihui YuZanbo DingZhoufei LiYujie ChenGuanhua XueJing YuanPublished in: Journal of biomedical science (2023)
The phage pK4-26 is a good antibiotic alternative and can effectively relieve pneumonia caused by multidrug-resistant K. aerogenes. It carries a depolymerase that removes biofilms, reduces virulence, and improves intrinsic immune sensitivity.