Response to comment on 'Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity'.

Published in: eLife (2019)

We respond to concerns expressed by Pacifici and Shore (2019) about a recent paper (Lees-Shepard and Goldhamer, 2018a) in which we reported that the drug palovarotene can have severe side effects in a mouse model of fibrodysplasia ossificans progressiva.

Keyphrases

mouse model
high fat diet induced
drug induced
early onset
oxidative stress
adverse drug
emergency department
adipose tissue
insulin resistance