Circulating Chromosome Conformation Signatures Significantly Enhance PSA Positive Predicting Value and Overall Accuracy for Prostate Cancer Detection.
Dmitri PchejetskiEwan HunterMehrnoush DezfouliMatthew SalterRyan PowellJayne GreenTarun NaithaniChristina KoutsothanasiHeba AlshakerJiten JaipuriaMartin John ConnorDavid Eldred-EvansFrancesca FiorentinoHashim Uddin AhmedAlexandre AkoulitchevMathias WinklerPublished in: Cancers (2023)
Our results demonstrate that combining the standard PSA readout with circulating chromosome conformations (PSE test) allows for significantly enhanced PSA PPV and overall accuracy for PCa detection. The PSE test is accurate, rapid, minimally invasive, and inexpensive, suggesting significant screening diagnostic potential to minimise unnecessary referrals for expensive and invasive MRI and/or biopsy testing. Further extended prospective blinded validation of the new combined signature in a screening cohort with low cancer prevalence would be the recommended step for PSE adoption in PCa screening.
Keyphrases
- prostate cancer
- radical prostatectomy
- loop mediated isothermal amplification
- minimally invasive
- magnetic resonance imaging
- copy number
- risk factors
- papillary thyroid
- real time pcr
- squamous cell carcinoma
- label free
- sensitive detection
- magnetic resonance
- genome wide
- dna methylation
- ultrasound guided
- molecular dynamics simulations
- computed tomography
- diffusion weighted imaging