Algorithms for early detection of silent liver fibrosis in the primary care setting - a scoping review.

Currently available algorithms for targeted screening for liver fibrosis perform better than the individual routine liver blood tests or liver ultrasonography. However, primary care physicians urgently need algorithms with even higher diagnostic accuracies than what is available today. The main limitation of the existing widely accessible algorithms, such as the FIB-4, are the large number of false positive tests, resulting in overdiagnosis and futile referrals to secondary care.