Celecoxib-tramadol co-crystal in patients with moderate-to-severe pain following bunionectomy with osteotomy: A phase 3, randomized, double-blind, factorial, active- and placebo-controlled trial.
Eugene R ViscusiOscar A deLeon-CasasolaJesús CebrecosAdam JacobsAdelaida MorteEsther OrtizMariano SustAnna VaquéIra GottliebStephen DanielsJoseph S GimbelDerek MusePeter WinkleMichael E KussSebastián VidelaNeus GascónCarlos Plata-SalamánPublished in: Pain practice : the official journal of World Institute of Pain (2022)
CTC provided greater analgesia than comparable daily doses of tramadol and celecoxib, with similar tolerability to tramadol. CTC is approved in the United States.