Multiple midline defects identified in a litter of golden retrievers following gestational administration of prednisone and doxycycline: a case series.

This case report is the first to describe midline defects in dogs that have been exposed to immunomodulatory therapy during gestation. A causative relationship between mid-gestational immunomodulatory exposure and midline defects cannot be proven, however, this case supports a clear association and provides case-based evidence to support its avoidance when possible.