Glymphatic system is newly discovered pseudolymphatic system in brain and it plays an important role in the removal of interstitial metabolic waste products. We discuss and review the role of glymphatic system in neurological diseases, especially focus on the potential of MRI modelling and its associated challenges to obtain useful new information related to understand the glymphatic system dynamics, pathways, and provide quantitative maps for diagnosis, monitoring and prognosis of the disease. The non-invasive nature of MRI might more readily help with translation of glymphatic measurements from the laboratory to the clinic.