Insulin-like growth factor 1 receptor mediated tyrosine 845 phosphorylation of epidermal growth factor receptor in the presence of monoclonal antibody cetuximab.
N Gopalakrishna IyerJames PriceShay BourgeoisEric ArmstrongShyhmin HuangPaul M HarariPublished in: BMC cancer (2016)
EGFR-IGF-1R interaction has a functional consequence of phosphorylation of EGFR Y845 in cetuximab resistant HNSCC cells and dual targeting of EGFR and IGF-1R is a promising therapeutic strategy.
Keyphrases
- epidermal growth factor receptor
- tyrosine kinase
- monoclonal antibody
- advanced non small cell lung cancer
- growth hormone
- induced apoptosis
- small cell lung cancer
- pi k akt
- cell cycle arrest
- protein kinase
- binding protein
- cancer therapy
- signaling pathway
- squamous cell carcinoma
- radiation therapy
- drug delivery
- oxidative stress
- endoplasmic reticulum stress