A Plasmodium falciparum genetic cross reveals the contributions of pfcrt and plasmepsin II/III to piperaquine drug resistance.

John KaneXue LiSudhir KumarKatrina A Button-SimonsKatelyn M Vendrely BrennemanHaley DahlhoffMackenzie A C SievertLisa A CheckleyDouglas A ShouePuspendra P SinghBiley A AbatiyowMeseret T HaileShalini NairAnn ReyesRupam TripuraTom PetoDysoley LekStefan H I KappeMehul DhordaStandwell C NkhomaIan H CheesemanAshley M VaughanTimothy J C AndersonMichael T Ferdig

Published in: bioRxiv : the preprint server for biology (2023)

allele. Our multi-gene model suggests an important role for both loci in the evolution of this ACT resistant parasite lineage.

Keyphrases

plasmodium falciparum
genome wide
copy number
dna methylation
single cell
genome wide association study
transcription factor
cell fate
drug administration