Th1 cytokines synergize to change gene expression and promote corticosteroid insensitivity in pediatric airway smooth muscle.

Devine JacksonJoshua WalumPriyanka BanerjeeBrandon W LewisY S PrakashVenkatachalem SathishZhaohui XuRodney D Britt

Published in: Respiratory research (2022)

Together, these novel studies show the combined effects of TNFα and IFNγ on pediatric ASM and implicate Th1-associated cytokines in promoting ASM inflammation and hypercontractility in severe asthma.

Keyphrases

smooth muscle
gene expression
oxidative stress
rheumatoid arthritis
dna methylation
immune response
childhood cancer