Exome Array Analysis Identifies a Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease.
Brian D HobbsMargaret M ParkerHan ChenTaotao LaoMegan HardinDandi QiaoIwona HawrylkiewiczPawel SliwinskiJae-Joon YimWoo Jin KimDeog Kyeom KimPeter J CastaldiCraig P HershJarrett MorrowBartolome R CelliVictor M Pinto-PlataGerald J CrinerNathaniel MarchettiRaphael BuenoAlvar AgustíBarry J MakeJames D CrapoPeter M CalverleyClaudio F DonnerDavid A LomasEmiel F M WoutersJorgen VestboPeter D ParéRobert D LevyStephen I RennardXiaobo ZhouNan M LairdXihong LinTerri H BeatyEdwin K SilvermanMichael H Chonull nullnull nullnull nullnull nullPublished in: American journal of respiratory and critical care medicine (2017)
In an exome array analysis of COPD, we identified nonsynonymous variants at previously described loci and a novel exome-wide significant variant in IL27. This variant is at a locus previously described in genome-wide associations with diabetes, inflammatory bowel disease, and obesity and appears to affect genes potentially related to COPD pathogenesis.
Keyphrases
- genome wide
- copy number
- chronic obstructive pulmonary disease
- dna methylation
- lung function
- type diabetes
- high throughput
- high resolution
- metabolic syndrome
- insulin resistance
- weight loss
- glycemic control
- cystic fibrosis
- weight gain
- high fat diet induced
- air pollution
- body mass index
- gene expression
- single cell
- skeletal muscle
- transcription factor