Organic Small Molecule Contrast Agent for Targeted Photoacoustic Imaging of Patient-Derived Brain Tumors.
Min WuKai XiaoXingang LiuYudan YangGousheng SongGelei XiaoQing LiuJian YuanJie LiuPublished in: Advanced healthcare materials (2022)
Traditional glioblastoma (GBM) cell lines do not maintain the heterogeneity of the original tumor, cell interactions, and therapy response, thus limiting their investigation in GBM theranostics. Herein, a kind of GBM tumor-targeting nanoparticles (NPs) TCFNP@iRGD are designed and constructed, which are generated by photoacoustic (PA) contrast agent 2-(3-cyano-4,5,5-trimethylfuran-2(5H)-ylidene) malononitrile (TCF)-OH through facile nanoprecipitation and decorated with an active targeting ligand iRGD. Their potential in GBM detection via PA imaging on glioma patient-derived cells intracranial xenograft models is evaluated for the first time. Excellent tumor-specific PA mapping performance of GBM is realized by TCFNP@iRGD, demonstrating its promising potential in the clinical diagnosis of GBM.
Keyphrases
- high resolution
- small molecule
- cancer therapy
- magnetic resonance
- single cell
- fluorescence imaging
- induced apoptosis
- reduced graphene oxide
- cell therapy
- stem cells
- magnetic resonance imaging
- wastewater treatment
- mass spectrometry
- contrast enhanced
- drug delivery
- human health
- computed tomography
- mesenchymal stem cells
- cell cycle arrest
- cell death
- endoplasmic reticulum stress
- label free
- gold nanoparticles
- risk assessment
- replacement therapy