Multi-omics analysis uncovered systemic lupus erythematosus and COVID-19 crosstalk.

Zekai NianYicheng MaoZexia XuMing DengYixi XuHanlu XuRuoyao ChenYiliu XuNan HuangFeiyang MaoChenyu XuYulin WangMengyuan NiuAqiong ChenXiangyang XueHuidi ZhangGangqiang Guo

Published in: Molecular medicine (Cambridge, Mass.) (2024)

The interaction between SLE and COVID-19 promotes the activation of the IFN-I/II-triggered JAK-STAT signaling pathway in monocytes/macrophages. These findings provide a new direction and rationale for diagnosing and treating patients with SLE-COVID-19 comorbidity.

Keyphrases

systemic lupus erythematosus
coronavirus disease
sars cov
disease activity
signaling pathway
dendritic cells
respiratory syndrome coronavirus
immune response
rheumatoid arthritis
pi k akt
epithelial mesenchymal transition
oxidative stress