Revision of serum ALT upper limits of normal facilitates assessment of mild liver injury in obese children with non-alcoholic fatty liver disease.

Yutian LuQiongdan WangLisha YuXueRui YinHuijie YangXi XuYing XiaYue LuoYing PengQigui YuZhanguo ChenJian YuMeimei LaiNan WuXiao-Ben PanXiao-Qun Zheng

Published in: Journal of clinical laboratory analysis (2020)

Serum ALT levels significantly correlated with abnormal BMI values in children, suggesting a rigorous BMI threshold is needed to establish the cutoffs for serum ULN-ALT in children. Besides, the revised serum ULN-ALT can uncover mild liver injury in obese children with NAFLD.

Keyphrases

liver injury
drug induced
young adults
adipose tissue
type diabetes
metabolic syndrome
total knee arthroplasty
obese patients
bariatric surgery
physical activity