A new role for vault RNA-TEP1 complexes in mRNA production in trypanosomes.

Published in: The Journal of biological chemistry (2020)

Vault RNAs, found in vault ribonucleoprotein complexes, are known to be one of many types of small noncoding RNAs (ncRNAs), but their specific function is not known. A new study identifies a small ncRNA from Trypanosome brucei as a vault RNA (vtRNA) based on sequence analysis and its association with the canonical vault component TEP1. Down-regulation of T. brucei vtRNA impairs mRNA splicing in a permeabilized cell system, suggesting new roles for these enigmatic biomolecules.

Keyphrases

single cell
cell therapy
binding protein
gene expression
bone marrow
nucleic acid