Sex differences in soluble prorenin receptor in patients with type 2 diabetes.

Bruna VisniauskasDanielle Y AritaCarla B RosalesMohammed A FerozChristina LuffmanMichael J AccavittiGabrielle DawkinsJennifer HongAndrew C CurnowTina K ThethiJohn J LefanteEdgar A JaimesFranck Mauvais-JarvisVivian A FonsecaMinolfa C Prieto

Published in: Biology of sex differences (2021)

In patients with type 2 diabetes, sPRR contributes to RAS stimulation in a sex-dependent fashion. In diabetic women, increased plasma sPRR parallels the activation of systemic RAS; while in diabetic men, decreased sPRR in urine matches intrarenal RAS stimulation. sPRR might be a potential indicator of intrarenal RAS activation and renal dysfunction in men and women with type 2 diabetes.

Keyphrases

wild type
type diabetes
wound healing
polycystic ovary syndrome
risk assessment
pregnant women
insulin resistance
drug induced