Hydrogen peroxide is necessary during tail regeneration in juvenile axolotl.
Belfran Carbonell MJuliana Zapata-CardonaJean Paul DelgadoPublished in: Developmental dynamics : an official publication of the American Association of Anatomists (2021)
These results show that H2 O2 is necessary and sufficient to promote tail regeneration in axolotls. Additionally, Akt signaling and Agr2 were identified as ROS targets, suggesting that ROS/H2 O2 is likely to regulate epimorphic regeneration through these signaling pathways. In addition, ROS/H2 O2 -dependent-Yap1 activity is required during tail regeneration.