A prospective clinical study on the mechanisms underlying critical illness myopathy-A time-course approach.
Nicola CaccianiÅsa SkärlénYa WenXiang ZhangAlex B AddinsallMonica Llano-DiezMeishan LiLennart GransbergYvette HedströmBo-Michael BellanderDavid NelsonJonas BergquistLars LarssonPublished in: Journal of cachexia, sarcopenia and muscle (2022)
The mechanical ventilation-induced lung injury with release of cytokines/chemokines and the complete mechanical silencing uniquely observed in immobilized ICU patients affecting skeletal muscle gene/protein expression are forwarded as the dominant factors triggering CIM.
Keyphrases
- mechanical ventilation
- skeletal muscle
- intensive care unit
- end stage renal disease
- acute respiratory distress syndrome
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- high glucose
- copy number
- genome wide
- clinical trial
- type diabetes
- adipose tissue
- endothelial cells
- dna methylation
- drug induced
- oxidative stress
- extracorporeal membrane oxygenation
- double blind