Genetic analysis in the bariatric clinic; impact of a PTEN gene mutation.
Mellody I CooimanLotte KleinendorstBert van der ZwaagIgnace M C JanssenFrits J BerendsMieke M van HaelstPublished in: Molecular genetics & genomic medicine (2019)
Our patient illustrates the importance of recognizing this serious genetic condition for which preventive cancer screening options are available. The positive weight loss results after Sleeve Gastrectomy suggest that this could be a successful treatment option for obesity patients with PTEN mutations.
Keyphrases
- weight loss
- bariatric surgery
- roux en y gastric bypass
- pi k akt
- cell proliferation
- gastric bypass
- papillary thyroid
- primary care
- case report
- squamous cell
- glycemic control
- genome wide
- metabolic syndrome
- obese patients
- signaling pathway
- type diabetes
- insulin resistance
- childhood cancer
- young adults
- squamous cell carcinoma