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Inhibition of CD146 attenuates retinal neovascularization via vascular endothelial growth factor receptor 2 signalling pathway in proliferative diabetic retinopathy.

Jianqiang LinKaixuan CuiYue XuXiaoyu TangYuxun ShiXi LuBoyu YangQingjing HeShanshan YuXiaoling Liang
Published in: Acta ophthalmologica (2021)
Our results indicated that CD146 was involved in the development of retinal neovascularization via VEGFR2 pathway. Anti-CD146 may be an innovative or adjuvant therapy, which provides a new direction for the treatment of PDR and other ocular neovascular diseases.
Keyphrases
  • diabetic retinopathy
  • vascular endothelial growth factor
  • optical coherence tomography
  • endothelial cells
  • nk cells
  • optic nerve
  • age related macular degeneration