Mir-4699 promotes the osteogenic differentiation of mesenchymal stem cells.

Vahedeh HosseiniMahdi ParyanAmeneh KoochakiHenry Manuel CesaireSamira Mohammadi-Yeganeh

Published in: Journal of bone and mineral metabolism (2023)

Our findings indicated that miR-4699 supported and synergized the BMP2-induced osteoblast differentiation of mesenchymal stem cells. We suggest, thereof, the utilization of hsa-miR-4699 for further in vivo experimental investigation to reveal the potential therapeutic impact of regenerative medicine for different types of bone defects.

Keyphrases

mesenchymal stem cells
cell proliferation
long non coding rna
long noncoding rna
umbilical cord
bone marrow
bone regeneration
high glucose
cell therapy
endothelial cells
single cell
gene expression
oxidative stress