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Sugar Alcohols and Organic Acids Synthesis in Yarrowia lipolytica: Where Are We?

Patrick FickersHairong ChengCarol Sze Ki Lin
Published in: Microorganisms (2020)
Sugar alcohols and organic acids that derive from the metabolism of certain microorganisms have a panoply of applications in agro-food, chemical and pharmaceutical industries. The main challenge in their production is to reach a productivity threshold that allow the process to be profitable. This relies on the construction of efficient cell factories by metabolic engineering and on the development of low-cost production processes by using industrial wastes or cheap and widely available raw materials as feedstock. The non-conventional yeast Yarrowia lipolytica has emerged recently as a potential producer of such metabolites owing its low nutritive requirements, its ability to grow at high cell densities in a bioreactor and ease of genome edition. This review will focus on current knowledge on the synthesis of the most important sugar alcohols and organic acids in Y. lipolytica.
Keyphrases
  • low cost
  • single cell
  • cell therapy
  • wastewater treatment
  • water soluble
  • healthcare
  • climate change
  • gene expression
  • stem cells
  • human health
  • cell wall