Association between HLA alleles and Epstein-Barr virus Zta-IgA serological status in healthy males from southern China.
Lei-Lei YuanChang-Mi DengWen-Qiong XueYong-Qiao HeTong-Min WangJiang-Bo ZhangDa-Wei YangTing ZhouZi-Yi WuYing LiaoMei-Qi ZhengDan-Hua LiLian-Jing CaoYi-Jing JiaWen-Li ZhangRuo-Wen XiaoLu-Ting LuoXia-Ting TongYan-Xia WuJing-Wen HuangWei-Hua JiaPublished in: The journal of gene medicine (2021)
Our study highlighted the pivotal role of genetic HLA variants in EBV reactivation and the etiology of NPC. Smokers with HLA-DRB1*09:01 have a significantly higher risk of being Zta-IgA seropositive, which indicates the necessity of smoking cessation in certain high-risk populations and also provide clues for further research on the etiology of NPC.