BCL6 attenuates hyperoxia-induced lung injury by inhibiting NLRP3-mediated inflammation in fetal mouse.

Dan ChenHui-Min ZhaoXian-Hui DengSheng-Peng LiMei-Hui ZhouYa-Xian WuYing TongRen-Qiang YuQing-Feng Pang

Published in: Experimental lung research (2024)

BCL6 inhibits NLRP3-mediated inflammation, attenuates alveolar simplification and dysregulated pulmonary vessel development in hyperoxia-induced BPD mice. Hence, BCL6 may be a target in treating BPD and neonatal diseases.

Keyphrases

oxidative stress
diabetic rats
high glucose
pulmonary hypertension
drug induced
signaling pathway
type diabetes
endothelial cells
insulin resistance