Intravenous immunoglobulin protects from experimental allergic bronchopulmonary aspergillosis via a sialylation-dependent mechanism.

Silvia BozzaFabian KäsermannSrini V KaveriLuigina RomaniJagadeesh Bayry

Published in: European journal of immunology (2018)

Intravenous immunoglobuin (IVIG) exerts protective effects in experimental allergic bronchopulmonary aspergillosis (ABPA) via a sialylation-dependent mechanism. The protection was associated with reduced recruitment of eosinophils, diminished goblet cell hyperplasia, suppressed Th2 and Th17 responses and reciprocally enhanced regulatory T cells and IL-10, and decreased IgE levels in the circulation.

Keyphrases

regulatory t cells
dendritic cells
high dose
single cell
allergic rhinitis
cell therapy
stem cells
mesenchymal stem cells
immune response